The enzyme reverse transcriptase converts single-stranded RNA molecules into double-stranded DNA molecules inside mature HIV viral capsids. We present a model for the uncoating of the HIV virus where the capsid uncoating process is driven by the confinement force exerted on the capsid wall porduced to the double-stranded DNA generated by reverse transcriptase.
CITATION STYLE
Rouzina, I., & Bruinsma, R. (2014). DNA confinement drives uncoating of the HIV Virus. European Physical Journal: Special Topics, 223(9), 1745–1754. https://doi.org/10.1140/epjst/e2014-02223-x
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