Abstract
The compound L-valine-3-{8-[(E)-2-[3-methoxyphenyl)ethenyl]-7-methyl-1- propargylxanthine-3-yl}propyl ester hydrochloride (MSX-4) was synthesized as an amino acid ester prodrug of the adenosine A2A receptor antagonist MSX-2. It was found to be stable in artificial gastric acid, but readily cleaved by pig liver esterase. © 2008 by MDPI.
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Vollmann, K., Qurishi, R., Hockemeyer, J., & Müller, C. E. (2008). Synthesis and properties of a new water-soluble prodrug of the adenosine A2A receptor antagonist MSX-2. Molecules, 13(2), 348–359. https://doi.org/10.3390/molecules13020348
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