Evaluation of CD40 and CD80 receptors in the colonic mucosal membrane of children with inflammatory bowel disease

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Abstract

Introduction. The most prevalent inflammatory bowel diseases (IBD) include ulcerative colitis (UC) and Crohn’s disease (CD). Immune processes play a vital role in the etiopathogenesis of these conditions, involving both cellular and humoral response mechanisms. The aim of this study was to quantify CD40-and CD80-positive cells in the biopsy specimens of large intestinal mucosa from children with IBD. Materials and method. The study comprised 38 children aged between 3-17 years (mean 11.5±3.7 years)-20 boys (52.6%) and 18 girls (47.4%). Eighteen patients were diagnosed with UC on the basis of clinical manifestation, endoscopic and histopathological findings. Mean age of this subgroup was 11.55±4.07 years. A group of 10 children (mean age 12.30±2.83) diagnosed with CD was also included. The control group comprised 10 IBD-free children (mean age 10.28±4.07 years). The surface expressions of CD40 and CD80 were analyzed in large intestine mucosa biopsy specimens, fixed in formaldehyde, embedded in paraffin, and cut with a microtome into 4 μm slices. Results. The number of CD40-and CD80-positive cells in the large intestinal mucosa of children with Crohn’s disease and ulcerative colitis was significantly higher than in the controls. The highest number of CD40+ and CD80+ cells was observed in the caecal mucosal membrane of Crohn’s disease patients and in the rectal mucosa of individuals with ulcerative colitis. Conclusion. IBD is characterized by elevated, segment-specific, expression of CD40 and CD80.

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Kamińska, B., Roszko-Kirpsza, I., Landowski, P., Szlagatys-Sidorkiewicz, A., Guzińska-Ustymowicz, K., & Maciorkowska, E. (2015). Evaluation of CD40 and CD80 receptors in the colonic mucosal membrane of children with inflammatory bowel disease. Annals of Agricultural and Environmental Medicine, 22(4), 695–699. https://doi.org/10.5604/12321966.1185778

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