Spontaneous tumors often contain heterogeneous populations of tumor cells with different tumor-initiating potentials or cancer cell "stemness." Clonal heterogeneity can be traced to specific locations inside a tumor where clones with different metastatic capabilities are identified, suggesting that the tumor microenvironment can exert a significant effect on the evolution of different clonal populations. Hypoxia is a common feature of tumor microenvironments and has the potential to facilitate malignant progression. This chapter provides a synopsis of hypoxia-regulated pathways implicated in the maintenance of cancer stem cells. © 2014 Springer Science+Business Media New York.
CITATION STYLE
Yun, Z., & Lin, Q. (2014). Hypoxia and regulation of cancer cell stemness. In Advances in Experimental Medicine and Biology (Vol. 772, pp. 41–53). Springer New York LLC. https://doi.org/10.1007/978-1-4614-5915-6_2
Mendeley helps you to discover research relevant for your work.