Pharmaceutical formulations of nimesulide

Abstract

Nimesulide is widely used to accomplish both topical and systemic therapeutic goals. Topical multi-dose semi-solid formulations for cutaneous application as well as single-dose preparations for bioadhesion onto the buccal mucosa were proposed for local and regional treatments. On the other hand, many different oral, rectal and injectable dosage forms were devised in order to attain a systemic therapeutic effect through the administration of nimesulide as described in Chapter 1. However, only a very limited number of the above dosage forms were developed and finally put on the marketplace.