An essential idea in the area of Systems Biology is that a good understanding of interactions between components is crucial for developing deep knowledge of the functioning of the system as a whole. Network analysis is an approach uniquely suited to uncover patterns and organizing principles in a wide variety of complex systems. In this chapter, we will give a detailed description of central network concepts and their algorithmic implementation, and demonstrate how they may be applied on two biological networks: the protein-interaction network of Mus musculus and the reconstructed genome-scale metabolic network of the bacterium Yersinia pestis. © 2012 Springer Science+Business Media, LLC.
CITATION STYLE
Zavareh, Z., & Almaas, E. (2012). Complex network analysis in microbial systems: Theory and examples. Methods in Molecular Biology, 881, 551–571. https://doi.org/10.1007/978-1-61779-827-6_19
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