RhoA/ROCK guides NMII on the way to MK polyploidy

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Abstract

A unique feature of megakaryocyte maturation is the switch from mitosis to replication of DNA without cell division, a process termed endomitosis. In this issue of Blood, Roy et al elegantly demonstrate that RhoA/ROCK signaling is critical for the differential activity and localization of nonmuscle myosin (NM) IIA and IIB isoforms at the megakaryocyte cleavage furrow, a key step in the induction of endomitosis.1

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Pleines, I., & Nieswandt, B. (2016, December 29). RhoA/ROCK guides NMII on the way to MK polyploidy. Blood. American Society of Hematology. https://doi.org/10.1182/blood-2016-11-746685

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