THE γ‐AMINOBUTYRIC ACID SYSTEM IN RAT CEREBELLUM DURING CANNABINOID‐INDUCED CATALEPTOID STATE

Abstract

Repeated, but not single, intraperitoneal injections of Δ1,6‐tetrahydrocannabinol (Δ1,6‐THC) 20 mg/kg to rats administered daily for two weeks, produced increased γ‐aminobutyric acid (GABA) concentration and decreased glutamic acid decarboxylase (GAD) activity in the cerebellum, as well as enhancement of [3H]‐GABA uptake by cerebellar crude synaptosomes. It seems that the motor impairment elicited by Δ1,6‐THC was not associated with the GABA system, but presumably might be related to changes in brain excitability. 1975 British Pharmacological Society