The development research of oxidase functional model iron complexes

Abstract

This paper describes research performed in the Laboratory of Organic Chemistry, Showa Pharmaceutical University. Oxidation reactions involving the oxidase can be divided roughly into two kinds of reactions: The first involves electron removal from an aromatic ring or an active CH-bond. The other reaction involves hydrogen abstraction from an inactive CH-bond. The oxidase models, Fe(DMF) 3Cl21+ and Fe(AN)63+/AN, which we have synthesized, have been shown to work by the former mechanism, and the models Fe(AN)63+-IO 4-/AN, Fe(AN)62+-Ac 2O-H2O2/AN, Fe(AN)62+-2PAH-5Py-Ac2O-H2O2/AN, Fe(PA)3(OH2)-H2O2/AN and Fe(PA) 3(OH2)-O2-electrolysis/AN do so by the latter mechanism. Further, we found some iron (II or III) picolinate-H 2O2/AN complexes have the 7α-hydroxylase-like activity. © 2004 The Pharmaceutical Society of Japan.