Endothelium-derived hyperpolarizing factor is defined as that substance which produces vascular smooth muscle hyperpolarization which cannot be explained by nitric oxide or by a cyclo-oxygenase product such as prostacyclin. The possibility that the factor is an epoxyeicosatrienoic acid or a cannabinoid agonist such as anandamide continues to be investigated, but definitive evidence in favour of either is lacking. The sensitivity of EDHF- mediated responses to charybdotoxin, to apamin or to mixtures of these two toxins may indicate the opening of more than one smooth muscle K-channel, but the possibility that these are located on the vascular endothelium is discussed.
CITATION STYLE
Edwards, G., & Weston, A. H. (1998). Endothelium-derived hyperpolarizing factor - A critical appraisal. Progress in Drug Research. Birkhauser Verlag AG. https://doi.org/10.1007/978-3-0348-8833-2_2
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