Phosphate induced crystal acute kidney injury - An under-recognized cause of acute kidney injury potentially leading to chronic kidney disease: Case report and review of the literature

Abstract

Acute phosphate nephropathy or nephrocalcinosis is a tubulointerstitial nephropathy characterized by tubular calcium phosphate deposition - crystal nephropathy - and slowly pro- gressive renal insuffciency during or following treatment with preparations containing sodium phosphate. We report a patient who developed nephrocalcinosis (crystal induced acute kidney injury) following the administration of a combination of oral and rectal sodium phosphate for treatment of postoperative constipation. A timely renal replacement therapy procedure may reverse the process of crystallization and the irreversible slope towards chronic dialysis. © 2013 Lochy et al, publisher and licensee Dove Medical Press Ltd.