Macrocyclic nickel complexes in DNA recognition and oxidation

Abstract

Nickel(II) macrocyclic complexes have been found to promote site- and conformation-specific oxidation of DNA. The systematic study of ligand effects has demonstrated that the crucial features in regulating DNA reactivity are in-plane donor strength and flexibility of the macrocyclic ligand. Based upon investigations of conformation specificity, macrocyclic ligand effects, and oxidant requirements, a mechanism has been proposed. In this mechanism, a nickel(III) complex containing a ligated guanine and oxidant molecule is postulated as a key intermediate. The oxidation of DNA has also been extended to macrocyclic complexes containing cobalt(III), rhodium(III) and chromium(III). © 1993 IUPAC