The present chapter reviews the development of the tumor-targeting amino-acid auxotrophic strain S. typhimurium A1 and the in vivo selection and characterization of the high-tumor-targeting strain S. typhimurium A1-R. Efficacy of S. typhimurium A1-R in nude-mouse models of prostate, breast, pancreatic, and ovarian cancer, as well as sarcoma and glioma in orthotopic mouse models is described. Also reviewed is effi cacy of S. typhimurium A1 - R targeting of primary bone tumor and lung metastasis of highgrade osteosarcoma, breast-cancer brain metastasis, and experimental breast-cancer bone metastasis in orthotopic mouse models. The efficacy of S. typhimurium A1-R on pancreatic cancer stem cells, on pancreatic cancer in combination with anti-angiogenic agents, as well as on cervical cancer, soft-tissue sarcoma, and pancreatic cancer patient-derived orthotopic xenograft (PDOX) mouse models, is also described.
CITATION STYLE
Hoffman, R. M. (2016). Tumor-targeting Salmonella typhimurium A1-R: An overview. In Methods in Molecular Biology (Vol. 1409, pp. 1–8). Humana Press Inc. https://doi.org/10.1007/978-1-4939-3515-4_1
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