Trypanocidal constituents in plants 2. Xanthones from the stem bark of Garcinia subelliptica

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Abstract

The constituents of the stem bark of Garcinia subellipticu (Guttiferae) were investigated based on its try-panocidal activity against epimastigotes of Trypanosoma cruzi, the etiologic agent for Chagas' disease. As the active components, nine xanthones were isolated including two new ones, 4-hydroxybrasilixanthone B and 1,3,5,6-tetrahydroxy-4,7,8-tri(3-methyl-2- butenyl)xanthone. Their structures were determined by spectroscopic analysis. Trypanocidal activity against trypomastigotes, an infectious form of T. cruzi, was also estimated as well as cytotoxic activity. Fukugetin, the major component of the bark, showed no activity.

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Abe, F., Nagafuji, S., Okabe, H., Higo, H., & Akahane, H. (2003). Trypanocidal constituents in plants 2. Xanthones from the stem bark of Garcinia subelliptica. Biological and Pharmaceutical Bulletin, 26(12), 1730–1733. https://doi.org/10.1248/bpb.26.1730

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