Natural killer (NK) cells have been known for many years as the lymphocyte subset characterized by the highest cytolytic potential against virus-infected and tumor-transformed cells. A surprisingly high number of surface molecules have been recognized that regulate human NK cell function. These include MHC-specific inhibitory receptors, which impair NK cells' ability to attack normal self-tissues, and activating receptors and coreceptors that allow them to recognize and kill transformed cells. The recent identification of some of the cellular ligands specifically recognized by these receptors/coreceptors contributes to elucidation of the mystery of the role played by NK cells in immune responses. © Springer-Verlag Berlin Heidelberg 2006.
CITATION STYLE
Bottino, C., Moretta, L., & Moretta, A. (2005). NK cell activating receptors and tumor recognition in humans. Current Topics in Microbiology and Immunology. https://doi.org/10.1007/3-540-27743-9_9
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