A 29-year-old woman presented with blurred vision and distal paresthesias. Her initial evaluation revealed severe bilateral optic disc edema with distal lower-extremity sensory and motor deficits and electrodiagnostic evidence of a length-dependent mixed demyelinating and axonal polyneuropathy. The results of routine diagnostic testing, including laboratory tests, magnetic resonance imaging, and lumbar puncture, were nondiagnostic. A targeted biopsy was ultimately required for diagnosis. In this article, we discuss the differential diagnosis and outline the clinical evaluation indicated for a patient presenting with demyelinating polyneuropathy and concurrent papilledema.
CITATION STYLE
Kung, N. H., Bartlett, N. L., Yaseen, N. R., Van Stavern, G. P., & Bucelli, R. C. (2015). A young woman with blurred vision and distal paresthesias. In JAMA Neurology (Vol. 72, pp. 1519–1526). American Medical Association. https://doi.org/10.1001/jamaneurol.2015.2390
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