Dementia risk among coronavirus disease survivors: A nationwide cohort study in south korea

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Abstract

We aimed to investigate whether coronavirus disease (COVID-19) survivors were at a higher risk of dementia diagnosis compared to controls at 6 months follow-up. Data pertaining to the period between 1 January and 4 June 2020, were extracted from the National Health Insurance Service (NHIS)-COVID-19 database in South Korea. Data on adults (≥20 years old) with no history of dementia, obtained from the NHIS-COVID-19 database, were included in the study. The endpoint of this study was the development of dementia, which was evaluated from 1 January to 1 December 2020. A total of 306,577 adults were included in the analysis, comprising 7133 COVID-19 survivors and 299,444 individuals in the control group. Among the subjects, new-onset dementia diagnosed in 2020 was recorded in 1.2% (3546 of 306,577). In the covariate-adjusted multivariable Cox regres-sion model, the incidence of dementia among COVID-19 survivors was 1.39-fold higher (hazard ratio: 1.39, 95% confidence interval: 1.05–1.85; p = 0.023) than that in the control group. At approxi-mately 6 months of follow-up, COVID-19 survivors were at a higher risk of dementia compared to other populations in South Korea.

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Park, H. Y., Song, I. A., & Oh, T. K. (2021). Dementia risk among coronavirus disease survivors: A nationwide cohort study in south korea. Journal of Personalized Medicine, 11(10). https://doi.org/10.3390/jpm11101015

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