Relative movements of domains in large molecules of the immune system

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Abstract

Molecular dynamics was used to simulate large molecules of the immune system (major histocompatibility complex class I, presented epitope, T-cell receptor, and a CD8 coreceptor.) To characterize the relative orientation and movements of domains local coordinate systems (based on principal component analysis) were generated and directional cosines and Euler angles were computed. As a most interesting result, we found that the presence of the coreceptor seems to influence the dynamics within the protein complex, in particular the relative movements of the two α-helices, Gαand Gα

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Schreiner, W., Karch, R., Ribarics, R., Cibena, M., & Ilieva, N. (2015). Relative movements of domains in large molecules of the immune system. Journal of Immunology Research, 2015. https://doi.org/10.1155/2015/210675

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