Generalized vitiligo

Abstract

Core Messages: The existence of various phenotypes among nonsegmental vitiligo (NSV) (e.g., Acrofacial or Vulgaris) is suggested by clinical observation and possibly by genetic associations. Half of initially focal vitiligo patients evolve into NSV. The fingers, hands and face are frequently reported to be the initial sites by the patients. In darker-skinned individuals, palms and soles have to be examined with Wood's lamp. Most of the spontaneous repigmentation re ported by the patients is correlated to sun exposure. Multichrome vitiligo refers to various degrees of depigmentation within a vitiligo macule, a phenomenon noted in dark skin. © 2010 Springer-Verlag Berlin Heidelberg.