The SNP rs4804611 in ZNF627 gene and the risk of myocardial infarction: A meta-analysis

Abstract

A single nucleotide polymorphism (rs4804611) in zinc finger protein 627 (ZNF627) gene has been demonstrated to be associated with the susceptibility to myocardial infarction (MI), but the results are inconsistent. Therefore, a meta-analysis of eligible studies reporting the association between rs4804611 and MI was carried out to enhance the reliability of published results. A systematic literature search was performed using PubMed, Web of Science, Cochrane Library to search English articles concerning the relation between rs4804611 and MI up to January, 2015. Summary odds ratios (OR) and 95% confidence interval (CI) were used to evaluate the risk of MI. The heterogeneity and publication bias of this study were also evaluated. Five eligible studies involving 11639 subjects (6299 patients and 5340 healthy controls) were included in this meta-analysis. Overall, the results indicated that rs4804611 polymorphism was associated with the risk of MI (GG vs. AA/AG: OR = 0.833, 95% CI = 0.704-0.985, P = 0.033). Furthermore, subgroup analyses also showed that rs4804611 polymorphism was associated with the risk of MI in Caucasian (GG vs. AA/AG: OR = 0.839, 95% CI = 0.704-0.999, P = 0.048). In conclusion, our meta-analysis suggests that the rs4804611 polymorphism in ZNF627 gene is associated with the risk of MI. However, further large scale case-control studies with rigorous design should be conducted to confirm the conclusion in the future.