Structural bioinformatics approaches to chemical senses

Abstract

A deep characterization of the molecular mechanisms underlying the functioning of the receptors involved in chemical sensing, is fundamental for gaining insights into the way our cells communicate with the external world. Unfortunately, the paucity of experimental structural information hampers such characterization. Protein structural bioinformatics, combined with computational biology and experimental techniques is the key to face these challenges. Here I will show our recent works regarding the bitter-taste signaling pathway. Moreover, I will also present some elements of the state of art of membrane protein structural bioinformatics field. © 2013 IFMBE.