Toll-deficient Drosophila is susceptible to Pythium insidiosum infection

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Abstract

There is a paucity of animal models of pythiosis, a life-threatening disease of humans and animals, the immunopathogenesis of which is poorly understood. A pythiosis model was developed by injecting Toll (Tl)-deficient Drosophila melanogaster flies with Pythium insidiosum zoospores. The infected Tl mutant flies had significantly lower survival rates (73.7%) than did control flies. This study reveals the important role of Tl pathway activation in fly immune response to pythiosis. © 2013 The Societies and Wiley Publishing Asia Pty Ltd.

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Zanette, R. A., Santurio, J. M., Loreto, É. S., Alves, S. H., & Kontoyiannis, D. P. (2013). Toll-deficient Drosophila is susceptible to Pythium insidiosum infection. Microbiology and Immunology, 57(10), 732–735. https://doi.org/10.1111/1348-0421.12082

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