GYKI 52466, an inhibitor of spinal reflexes is a potent quisqualate antagonist

  • Tarnawa I
  • Engberg I
  • Flatman J
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Abstract

GYKI 52466 is a 2,3-benzodiazepine compound, which inhibits spinal reflexes in cats. Contrary to the classical benzodiazepines (e.g. diazepam), GYKI 52466 does not potentiate the inhibitory action of gamma-amino butyric acid, but seems to affect excitatory processes in the spinal cord directly.

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Tarnawa, I., Engberg, I., & Flatman, J. A. (1990). GYKI 52466, an inhibitor of spinal reflexes is a potent quisqualate antagonist. In Amino Acids (pp. 538–546). Springer Netherlands. https://doi.org/10.1007/978-94-011-2262-7_63

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