Accuracy improvement of lung cancer detection based on spatial statistical analysis of thoracic CT scans

Abstract

This paper describes a novel discrimination method of lung cancers based on statistical analysis of thoracic computed tomography (CT) scans. Our previous Computer-Aided Diagnosis (CAD) system can detect lung cancers from CT scans, but, at the same time, yields many false positives. In order to reduce the false positives, the method proposed in the present paper uses a relationship between lung cancers, false positives and image information on CT scans. The trend of variation of the relationships is acquired through statistical analysis of a set of CT scans prepared for training. In testing, by use of the trend, the method predicts the appearance of lung cancers and false positives in a CT scan, and improves the accuracy of the previous CAD system by modifying the system's output based on the prediction. The method is applied to 218 actual thoracic CT scans with 386 actual lung cancers. Receiver operating characteristic (ROC) analysis is used to evaluate the results. The area under the ROC curve (Az) is statistically significantly improved from 0.918 to 0.931. © Springer-Verlag Berlin Heidelberg 2007.