Rad52/Rad59-dependent recombination as a means to rectify faulty Okazaki fragment processing

Abstract

Background: How faulty Okazaki fragments are repaired remains unclear. Results: The DNA annealing activity of Rad52 and sister chromatid cohesion are important in the repair of faulty Okazaki fragments. Conclusion: Rad52/Rad59-mediated sister chromatid recombination is a major means of repairing faulty Okazaki fragments. Significance: The faithful repair of faulty Okazaki fragments is critical for genome stability. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.