Extensively drug-resistant (XDR) tuberculosis (TB) represents a serious and growing problem in both endemic and non-endemic countries. We describe a 2.5- year-old girl with XDR-pulmonary TB and an 18-monthold boy with pre-XDR-central nervous system TB. Patients received individualized treatment with second-line anti-TB agents based on genotypic and phenotypic drug susceptibility testing results. Both children achieved culture conversion 3 months and 1 month after treatment initiation, respectively. The child with XDR-pulmonary TB showed evidence of cure while treatment adverse events were managed without treatment interruption. The child with pre-XDR-central nervous system TB after 6-month hospitalization with multiple infectious complications had a dismal end due to hepatic insufficiency possibly related to anti-TB treatment. This is the first report of children with pre-XDR and XDR TB in Greece, emphasizing the public health dimensions and management complexity of XDR TB. © Springer-Verlag 2012.
CITATION STYLE
Katragkou, A., Antachopoulos, C., Hatziagorou, E., Sdougka, M., Roilides, E., & Tsanakas, J. (2013). Drug-resistant tuberculosis in two children in Greece: Report of the first extensively drug-resistant case. European Journal of Pediatrics, 172(4), 563–567. https://doi.org/10.1007/s00431-012-1811-8
Mendeley helps you to discover research relevant for your work.