Discrepancy between pregnancy dating methods affects obstetric and neonatal outcomes: A population-based register cohort study

Abstract

To assess associations between discrepancy of pregnancy dating methods and adverse pregnancy, delivery, and neonatal outcomes, odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for discrepancy categories among all singleton births from the Medical Birth Register (1995-2010) with estimated date of delivery (EDD) by last menstrual period (LMP) minus EDD by ultrasound (US) -20 to +20 days. Negative/positive discrepancy was a fetus smaller/larger than expected when dated by US (EDD postponed/changed to an earlier date). Large discrepancy was <10th or >90th percentile. Reference was median discrepancy ±2 days. Odds for diabetes and preeclampsia were higher in pregnancies with negative discrepancy, and for most delivery outcomes in case of large positive discrepancy (+9 to +20 days): shoulder dystocia [OR 1.16 (95% CI 1.01-1.33)] and sphincter injuries [OR 1.13 (95% CI 1.09-1.17)]. Odds for adverse neonatal outcomes were higher in large negative discrepancy (-4 to -20 days): low Apgar score [OR 1.18 (95% CI 1.09-1.27)], asphyxia [OR 1.18 (95% CI 1.11-1.25)], fetal death [OR 1.47 (95% CI 1.32-1.64)], and neonatal death [OR 2.19 (95% CI 1.91-2.50)]. In conclusion, especially, large negative discrepancy was associated with increased risks of adverse perinatal outcomes.