Infarcted fibroadenoma of the breast: Report of two new cases with review of the literature

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Abstract

Introduction: Fibroadenomas are the most common benign breast tumors in young women. Infarction is rarely observed in fibroadenomas and when present, it is usually associated with pregnancy or lactation. Infarction can exceptionally occur as a complication of previous fine-needle aspiration biopsy or during lactation and pregnancy.Materials and methods: Retrospective review of 650 cases of fibroadenomas diagnosed at our institution during the 8-years period identified two cases of fibroadenomas with infarction (rate ~0.3%).Results: Two partially infarcted fibroadenomas were diagnosed on core biopsy and frozen section in an adolescent girl (13 years old) and in a young woman (25 years old), respectively. No preceding fine-needle aspiration biopsy was performed in these cases, nor were the patients pregnant or lactating at the time of the diagnosis.Conclusion: Spontaneous infarction within fibroadenoma is a rare phenomenon in younger patients. The presence of necrosis on core biopsy or frozen section should be cautiously interpreted and is not a sign of malignancy.Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1556060549847356. © 2013 Skenderi et al; licensee BioMed Central Ltd.

Figures

  • Figure 1 Ultrasound examination (A) and MRI (B) of the breast (Case 40 mm.
  • Figure 2 (A): Hematoxylin & Eosin (H&E) slide of a core biopsy showing a classical fibroadenoma with an area of necrosis (arrow) (5x); (B): An excision biopsy revealing a fibroadenoma with a focal morphologic features of benign phyllodes tumor (H&E, 10x); (C): A zone of necrosis (H&E, 10x); (D): Squamous metaplasia, observed in close proximity of necrotic foci, reminiscent of the so-called necrotizing syringometaplasia in the skin or necrotizing sialometaplasia in salivary glands (H&E, 10x).
  • Figure 3 (A): A classical cellular (juvenile) fibroadenoma (H&E, 10x); (B

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CITATION STYLE

APA

Skenderi, F., Krakonja, F., & Vranic, S. (2013). Infarcted fibroadenoma of the breast: Report of two new cases with review of the literature. Diagnostic Pathology, 8(1). https://doi.org/10.1186/1746-1596-8-38

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