Abstract
It happens at the Met: The DNA platination rate is substantially enhanced by methionine binding to trans-coordinated platinum antitumor drugs (see scheme). Platinum-methionine intermediates were also formed in a cell system and could play a major role in the mechanism of action of trans compounds. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
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Li, C., Li, Z., Sletten, E., Arnesano, F., Losacco, M., Natile, G., & Liu, Y. (2009). Methionine can favor DNA platination by trans-coordinated platinum antitumor drugs. Angewandte Chemie - International Edition, 48(45), 8497–8500. https://doi.org/10.1002/anie.200902948
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