Anti-N-methyl-D-aspartate receptor encephalitis (case reports)

Abstract

The article describes the clinical cases of anti-N-methyl- D-aspartate receptor encephalitis of two patients. An analysis of the dynamics of neurologic symptoms, the results of neurovisualization and neurophysiological examinations was carried out. It was shown that in patients with Anti- N-methyl-D-aspartate receptor encephalitis, neurological symptoms are similar in their manifestations with symptoms of virus encephalitis. At the same time, the mechanism of development and etiology of this form of autoimmune pathology is not understood. Also, no pathognomonic changes were detected for MRI of the brain, PET, EEG for Anti-N-methyl- D-aspartate receptor encephalitis. The authors conclude that the diversity of neurological symptoms in patients with anti- N-methyl-D-aspartate receptor encephalitis may be due not only to dysfunction of brain structures due to disruption of NMDA receptor activity, but also to a reversible disruption of functional interrelationships between different parts of the brain.