Notch drives critical decisions in a multitude of developmental decisions in many invertebrate and vertebrate organisms including flies, worms, fish, mice and humans. Therefore, it is not surprising that Notch family members also play a key role in cell fate choices in the vertebrate immune system. This review highlights the critical function of Notch in the development of mature T lymphocytes from hematopoietic precursors and describes the role of Notch in mature T cell activation, proliferation and differentiation.
CITATION STYLE
Vijayaraghavan, J., & Osborne, B. A. (2018). Notch and t cell function – A complex tale. In Advances in Experimental Medicine and Biology (Vol. 1066, pp. 339–354). Springer New York LLC. https://doi.org/10.1007/978-3-319-89512-3_17
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