Abstract
Colon cancer is a heterogeneous tumor driven by subpopulations of cancer stem cells (CSCs). We recently used patient-derived organoids (PDOs) to demonstrate that CSC survival is regulated by autocrine non-canonical Hedgehog signaling, which acts as a positive regulator of Wnt signaling to block CSC differentiation.
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APA
Regan, J. L. (2018). Cell fate in colon cancer stem cells: To GLI or not to GLI?*. Molecular and Cellular Oncology, 5(3). https://doi.org/10.1080/23723556.2018.1445940
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