Moderate intensity, but not high intensity, treadmill exercise training alters power output properties in myocardium from aged rats

15Citations
Citations of this article
47Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Aging is characterized by a progressive decline in cardiac function, but endurance exercise training has been shown to retard a number of deleterious effects of aging. However, underlying mechanisms by which exercise training improves age-related decrements in myocardial contractile function are not well understood. The purpose of this study was to determine the effects of exercise training on power output properties in permeablized (skinned) myocytes of old rats. Thirty-month-old rats were divided into sedentary control (C) and groups undergoing 11 weeks of treadmill exercise training at moderate intensity (MI) and at high intensity (HI). Peak power output normalized to maximal force was significantly increased in MI but not in HI compared to C with significant increases in atrial myosin light chain 1 in ventricle. These results suggest that MI exercise training is beneficial as a significant increase was seen in the ability of the myocardium to do work, but this effect was not seen with HI training. © 2012 The Author.

References Powered by Scopus

Exercise as cardiovascular therapy

452Citations
N/AReaders
Get full text

Myocardial aging: Functional alterations and related cellular mechanisms

250Citations
N/AReaders
Get full text

Intensity-controlled treadmill running in rats: VO<inf>2 max</inf> and cardiac hypertrophy

248Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Effect of age and exercise on the viscoelastic properties of rat tail Tendon

43Citations
N/AReaders
Get full text

Force properties of skinned cardiac muscle following increasing volumes of aerobic exercise in rats

10Citations
N/AReaders
Get full text

Esophageal morphometric and biomechanical changes during aging in rats

9Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Chung, E., & Diffee, G. M. (2012). Moderate intensity, but not high intensity, treadmill exercise training alters power output properties in myocardium from aged rats. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 67(11), 1178–1187. https://doi.org/10.1093/gerona/gls146

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 15

44%

Researcher 13

38%

Professor / Associate Prof. 5

15%

Lecturer / Post doc 1

3%

Readers' Discipline

Tooltip

Medicine and Dentistry 12

41%

Agricultural and Biological Sciences 7

24%

Biochemistry, Genetics and Molecular Bi... 7

24%

Nursing and Health Professions 3

10%

Save time finding and organizing research with Mendeley

Sign up for free