Mode of actions of bisphosphonates in dental implant procedure: An overview

Abstract

Bisphosphonates (BP) are the most commonly used drug forthe past few years for the treatment of various types of bone disorders and malignancies. Osteonecrosis of the jaw (ONJ) is most devitalizing but still not has been properly acknowledged as of now. These drugs suppress bone turnover by decreasing osteoclastic activity. This article points in featuring the key and pharmaco-physiological system of activity of both N2 and non N2 bisphosphonates on bone and activity of bisphosphonates on dental implants, particularly their commitment in success of the implant and the present suggestions and rules for implant treatment in patients who are on bisphosphonate therapy. This article also includes the prevention and management for decreasing the cumulative IV bisphosphonate dose, stoppage of bisphosphonates before any invasive dental treatment, and in ONJ using serum beta-CTX-1 in assessment of risk. “Drug Holiday” for the invasive dental procedure is incorporated as well.