New acylides: Synthesis of 3-O-[γ-(4-oxo-2-arylthiazolidin-3-yl) butyryl]erythromycin A derivatives

Abstract

In search of new erythromycin derivatives 3-O-[γ-(4-oxo-2-aryl- thiazolidin-3-yl)butyryl]erythromycin A derivatives have been synthesized. The 3-hydroxy group was derivatised to a primary amine and subsequently the thiazolidinone nucleus was generated at the amino functionality through DCC mediated one-pot three-component reaction in good yields. © 2008 Pandey et al; licensee Beilstein-Institut.