Itraconazole for the Treatment of Cryptococcosis in Cats

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Abstract

Itraconazole was used in 35 cats with cryptococcosis. Treatment response was determined by comparing clinical signs before, during, and after treatment. It could not be evaluated in 7 cats because they died during treatment from causes unrelated to cryptococcosis. Of the remaining 28 cats, treatment response was classified as success in 16 cats (57%), as improvement in 8 cats (29%), and as a failure in 4 (14%). The failures were due to death or euthanasia from drug toxicity (1 cat), progressive fungal disease (2 cats), and relapse 1 year after treatment (1 cat). The cats that improved did not undergo a 1 ‐year posttreatment evaluation because they were lost to follow‐up (3 cats), died or were euthanatized for other reasons (4 cats), or had a noncompliant owner (1 cat). For the 16 cats in which treatment was successful, the median itraconazole dose was 13.8 mg/kg body weight daily (range, 10.9 to 26.7 mg/kg/d), and the median duration of treatment was 8.5 months (range, 4 to 16 months). Five of these cats had previously been treated unsuccessfully with ketoconazole. © 1995 American College of Veterinary Internal Medicine

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Medleau, L., Jacobs, G. J., & Marks, M. A. (1995). Itraconazole for the Treatment of Cryptococcosis in Cats. Journal of Veterinary Internal Medicine, 9(1), 39–42. https://doi.org/10.1111/j.1939-1676.1995.tb03270.x

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