How best to improve survival in hemodialysis patients: Solute clearance or volume control

Abstract

How much dialysis is required for optimal well-being and long-term survival? The Frequent Hemodialysis Network completed two prospective trials examining the effect of more frequent, short hours and, now, of nocturnal hemodialysis compared with standard thrice-weekly treatments. Whereas the short-hours trial reported benefits with more frequent dialysis, somewhat paradoxically, nocturnal hemodialysis had fewer adVantages. However, this trial was probably unDerpowered, and confounded by the beneficial effects of home hemodialysis in the control group. © 2011 International Society of Nephrology.