Genetic Polymorphism of N-Acetylation of Isoniazid with Non-insulin-dependent Diabetes Mellitus Patients in Japanese

Abstract

1. Determination of isoniazid acetylation phenotype was carried out in 213 Japanese patients with pulmonary tuberculosis (control group) and 52 Japanese patients with both non-insulin-dependent diabetes mellitus and pulmonary tuberculosis (NIDDM group). 2. Distribution of the log (INH/AcINH) ratio of the Japanese population was observed in the two groups. 3. Assuming an antimode of 0. 6, the proportion of slow acetylators was found to be 10.0% in Japanese pulmonary tuberculosis patients, and 3.6% in Japanese NIDDM patients with pulmonary tuberculosis. These differences were not significant statistically. © 1992, The Japanese Society of Clinical Pharmacology and Therapeutics. All rights reserved.