PDGF

Abstract

Platelet-derived growth factor (PDGF) is a family of isoforms consisting of homodimers of A-, B-, C-, and D-polypeptide chains and the PDGF-AB heterodimer. The PDGF isoforms stimulate cell proliferation, survival and migration of fibroblasts, smooth muscle cells, pericytes, glial cells, and certain other cell types, via binding to a- and ß-tyrosine kinase receptors. Activating mutations of PDGF receptors, or overproduction of PDGF-BB, has been observed in certain tumor types. PDGF has also an important role in the stimulation of cells in the stroma of solid tumors. Targeting of PDGF signaling may thus be of clinical value in tumor treatment.