Matrix-induced autologous chondrocyte implantation

Abstract

Chondral injuries are common in the knee. The use of chondrocyte implantation as a treatment began in the 1970s and has progressed through several generations. The third-generation technique, matrix-induced autologous chondrocyte implantation (MACI), involves suspending cultured chondrocytes in a type I/III collagen bilayer which is then fixed to the defect using fibrin glue. Current pre- and post-operative management is similar to that used with traditional autologous chondrocyte implantation (ACI). Research into clinical and histological outcomes following MACI is ongoing but initial results appear encouraging.