Caspase Inhibition, Specifically

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Abstract

In this issue of Structure, Grütter and coworkers report mutagenesis of ankyrin repeat proteins to generate the first specific, tight-binding caspase inhibitor selectively targeting caspase-2 (Schweizer et al., 2007). Interestingly, this inhibitor operates by an allosteric mechanism that does not target the enzyme active site. © 2007 Elsevier Ltd. All rights reserved.

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Salvesen, G. S., & Riedl, S. J. (2007, May 16). Caspase Inhibition, Specifically. Structure. https://doi.org/10.1016/j.str.2007.04.006

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