Integration of Molecular Signaling into Multiscale Modeling of Cancer

Abstract

Multiscale modeling has now been well-accepted as a powerful tool to quantitatively represent, simulate, understand, and predict cancer progression and development across multiple biological scales. In this chapter, we focus on a specific type of multiscale cancer models where molecular signaling profiles are explicitly linked to the determination of cellular phenotypic changes. These models are particularly suitable for exploring the relationship between signaling dynamics within each individual cancer cell and the emergent cancer behavior on the multicellular level. We also discuss current challenges and future directions of this molecular signaling-incorporated multiscale cancer modeling approach.