Malondialdehyde levels and clinical outcomes assessed by the modified Rankin scale in patients with acute intracerebral hemorrhagic stroke

Abstract

Background: Oxidative stress plays an important role in secondary brain injury after a stroke of intracerebral hemorrhage. This study aimed to determine the association between malondialdehyde (MDA) levels with clinical outcomes assessed using the modified Rankin Scale (mRS) in patients with acute intracerebral hemorrhagic stroke. Methods: A cohort study was enrolled in patients with intracerebral hemorrhagic stroke in Dr. Soetomo General Hospital Surabaya, Indonesia. The study subjects were blood drawn for the examination of MDA levels at hospital admission, and the examination of clinical outcomes was assessed using the mRS when the patient was discharged from the hospital. Results: In 34 study subjects, 23 subjects with poor mRS and 11 subjects with good mRS were obtained. The results of the study analysis showed that subjects who had MDA levels >494.95 ng/mL with poor mRS were 17 subjects (73.9 %), higher than those with good mRS, 3 subjects (27.3 %). There were not statistically significant differences between age, GCS, bleeding volume, and MDA with clinical outcomes (p>0.06). However, there was an association between MDA levels clinical outcomes with p = 0.023 and relative risk (RR) of 1.983 (95 % CI 1.054-3.732). Conclusion: There was a significant association between MDA levels and clinical outcomes assessed using the mRS in patients with acute intracerebral hemorrhagic stroke.