Experimental models of polycystic ovary syndrome

Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrine metabolic disorder in women. Although many animal and human studies have been conducted, mechanisms involved in polycystic ovary formation and related metabolic dysfunction have not been fully understood,. Different techniques have been tried on animals to induce PCOS. Chronologically, the experimental methods used to induce PCOS included dehydroepiandrosterone application, estradiol valerate injection, fetal androgen administration, antiprogesterone (RU486) application and letrozole use. All of these models were described in this review article.