Clinical manifestations

Abstract

Brugada syndrome (BrS) is responsible for 4% of all sudden deaths and 20% of sudden cardiac deaths (SCD) in those without structural heart disease and is a leading cause of death in subjects under the age of 40 years. Patients with BrS may present with syncope due to polymorphic ventricular tachycardia, VF or resuscitated SCD. Palpitations, presyncope, and syncope are the three most important symptoms requiring further characterization in patients suspected of having ventricular arrhythmias due to BrS. The syndrome typically manifests during adulthood and clinical presentation peaks in the third and fourth decade of life.