Total syntheses of all the amathaspiramides

Abstract

Six in one blow: Total syntheses of all the amathaspiramide alkaloids have been accomplished. Rapid construction of the diazaspiro[3.3]nonane core combined with regio- and diastereoselective reduction of the cyclic imide moiety with DIBAL established the route to the common structural motif. The late-stage reduction of the lactam to an imine functionality mediated by Schwartz's reagent was the key to the streamlined syntheses. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.