Lithium acts biochemically through the inositol depletion in brain cortex. At low doses, however, it is partly effective and/or ineffective, whereas in high concentrations is toxic. We would like to make one point about this review. In fact, in our view, the patient should be given a support to correct hypernatremia and even sodium levels should be tested serially—along with serum lithium concentrations—because high sodium levels reduce the rate of elimination of lithium. Lithium is mainly a neurotoxicant. Lithium-related central nervous system toxicity as well as the cardiovascular and thyroid changes are most likely due to the cations (Na2+ and K+) competition.
CITATION STYLE
Pigatto, P. D., Dell’Osso, B., & Guzzi, G. (2016). Lithium overdosage and related tests. International Journal of Bipolar Disorders. SpringerOpen. https://doi.org/10.1186/s40345-015-0044-y
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