Long-term low-dose warfarin use is effective in the prevention or recurrent venous thromboembolism: Yes

Abstract

In sum, in choosing between low-intensity warfarin and full-intensity warfarin for long-term prophylaxis, physicians must balance the benefit-to-risk ratio for individual patients. The overly simplistic conclusion that any one dosing regimen is 'optimal' for all patients will fail to provide the best care for each individual and must be carefully guarded against. Following an initial period of anticoagulation with full-intensity warfarin, the low-intensity approach is more than adequate for most patients and is likely to provide the best overall benefit-to-risk ratio for many. For individuals where risks of recurrence are exceptionally high or bleeding risks unusually low, long-term full-intensity warfarin can be considered as long as careful monitoring for toxicity is undertaken. © 2004 International Society on Thrombosis and Haemostasis.