Gastric cancer is the second major cancer diagnosed worldwide. Cytokines, chemokines, metalloproteinases, prostaglandins, and reactive oxygen nitrogen species induce, amplify, and sustain inflammation (in the lining of the stomach) in the host. Signalling pathways like β-catenin, NF-κB, etc. bring about changes in the genetic material leading to diversification of genetic material. Genetic diversification in oncogenes and tumour suppressor genes leads to gastric cancer. Transcriptional factors’ role in apoptosis, cell cycle, cell proliferation, and metastasis (adhesion, invasion, migration, angiogenesis) is well known and established. The role and regulation of transcriptional factors in relation to gastric cancer was reviewed.
CITATION STYLE
Neelapu, N. R. R. (2018). Role and regulation of transcriptional factors in gastric cancer. In Role of Transcription Factors in Gastrointestinal Malignancies (pp. 105–128). Springer Singapore. https://doi.org/10.1007/978-981-10-6728-0_9
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