Twenty five patients with acute liver failure were measured for hepatic venous pressure gradient as an index of portal pressure during the course of a transjugular liver biopsy. Hepatic venous pressure gradient ranged from 4 to 24.5 mm Hg with a mean of 12·8 (5·3) mm Hg (normal values <5mm Hg). AU patients but one had increased portal pressure gradient. Portal hypertension correlated with the degree of architectural distortion of the liver, as suggested by a direct correlation between hepatic venous pressure gradient and the area of reticulin collapse, evaluated by means of a morphometric analysis on Sirius red stained liver slides (r=0.43, p<005). Hepatic venous pressure gradient was significantly higher in patients with ascites (15·1 (5) mm Hg, n=15) or renal failure (14.4 (5·3) mm Hg, n=16) than in those without (9·3 (3·4) mm Hg and 10·1 (4) mm Hg, respectively; p<0·05). Portal hypertension was associated with systemic vasodilation and a hyperkinetic circulatory state, with decreased arterial pressure, and peripheral resistance and increased cardiac output.
CITATION STYLE
Navasa, M., Garcia-Pagan, J. C., Bosch, J., Riera, J. R., Bafnares, R., Mas, A., … Rodes, J. (1992). Portal hypertension in acute liver failure. Gut, 33(7), 965–968. https://doi.org/10.1136/gut.33.7.965
Mendeley helps you to discover research relevant for your work.