Portal hypertension in acute liver failure

55Citations
Citations of this article
26Readers
Mendeley users who have this article in their library.

Abstract

Twenty five patients with acute liver failure were measured for hepatic venous pressure gradient as an index of portal pressure during the course of a transjugular liver biopsy. Hepatic venous pressure gradient ranged from 4 to 24.5 mm Hg with a mean of 12·8 (5·3) mm Hg (normal values <5mm Hg). AU patients but one had increased portal pressure gradient. Portal hypertension correlated with the degree of architectural distortion of the liver, as suggested by a direct correlation between hepatic venous pressure gradient and the area of reticulin collapse, evaluated by means of a morphometric analysis on Sirius red stained liver slides (r=0.43, p<005). Hepatic venous pressure gradient was significantly higher in patients with ascites (15·1 (5) mm Hg, n=15) or renal failure (14.4 (5·3) mm Hg, n=16) than in those without (9·3 (3·4) mm Hg and 10·1 (4) mm Hg, respectively; p<0·05). Portal hypertension was associated with systemic vasodilation and a hyperkinetic circulatory state, with decreased arterial pressure, and peripheral resistance and increased cardiac output.

Cite

CITATION STYLE

APA

Navasa, M., Garcia-Pagan, J. C., Bosch, J., Riera, J. R., Bafnares, R., Mas, A., … Rodes, J. (1992). Portal hypertension in acute liver failure. Gut, 33(7), 965–968. https://doi.org/10.1136/gut.33.7.965

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free